Professor Paolo Samorì has pioneered innovative directions in nanoscale chemistry by harnessing supramolecular design principles to construct functional interfaces with precisely tailored structures and properties. His research has demonstrated that carefully controlled molecular organization at interfaces can give rise to emergent electronic, optical, sensing, and energy-related functionalities. By integrating supramolecular chemistry with nanoscience, he has introduced powerful approaches for creating multifunctional interfacial systems and devices relevant to two-dimensional (2D) materials, organic optoelectronics, sensors, and sustainable energy technologies. At the core of Samorì’s scientific vision is the belief that interfacial chemistry and molecular self-assembly are fundamental to the design of advanced functional materials. His work focuses on combining organic, polymeric, and inorganic components through both covalent and non-covalent interactions, enabling the fabrication of hybrid architectures with predetermined physical and chemical characteristics. Through precise control of molecular arrangements at surfaces and interfaces, he has significantly deepened our understanding of how nanoscale structure influences macroscopic performance in technologically important materials. His research merges state-of-the-art nanofabrication and characterization methods with concepts from supramolecular chemistry and interface science to engineer nanomaterials and devices with well-defined structures and functions. A major theme of his work is the manipulation of molecular organization at solid–liquid and solid–solid interfaces, where interfacial effects govern electronic, optical, catalytic, and sensing behaviour. This interdisciplinary approach has established him as a leading figure in supramolecular chemistry, nanochemistry, interfacial science, and materials research. During the last five years Professor Samori’s contributions have generated significant advances in several interconnected areas centered on functional interfacial architectures and 2D materials.